Abstract: Objectives Aimed at exploring the pulsating pressure characteristics and control schemes induced by propellers of a high-speed three-propeller ship. Methods The CFD method was used to numerically predict the pulsating pressure induced by propellers of the high-speed three-propeller ship. The spectral characteristics of the pulsating pressure and its spatial distribution on the hull shell plate were analyzed, as well as the influence of tip distance and propeller speed on the pulsating pressure. The control effects of cylindrical and arched vibration isolation holes on the pulsating pressure were compared. Results The pulsating pressure induced by propellers on the hull shell plate is mainly composed of the blade frequency component, and the spatial distribution characteristics of pulsating pressure are different from those of single-propeller ships. Reducing the propeller speed can significantly reduce the pulsating pressure induced by propellers, and increasing the propeller tip clearance can significantly reduce the pulsating pressure on the hull shell plate. The arched vibration isolation hole not only reduces the maximum pulsating pressure of the hull shell plate above propellers by about 60%, but also has a relatively small impact on the hull structure. Conclusions The research can provide guidance for the prediction and control of pulsating pressure in high-speed three-propeller ships.