Abstract: Objectives Lightweight, low space occupation and high anti-nuclear explosion performance structures using conventional metal materials are currently the difficulties in the field of Marine structure safety design. This paper proposes a super-structure sandwich panel solution with a quasi-static conversion effect during the impact process for the anti-nuclear explosion protection design of key cabins in a certain deep-sea and far-sea large scientific facility. Methods First, a three-dimensional negative Poisson’s ratio corrugated tube metamaterial structure, capable of converting nonlinear impact processes into quasi-static processes, is introduced. Next, while ensuring comparable weight and spatial occupancy, a sandwich bulkhead incorporating this metamaterial and a conventional bulkhead are designed for the critical protective compartment of the deep-sea mega-science facility. Through numerical simulations, the effects of the unit cell angle and wall thickness of the three-dimensional negative Poisson’s ratio corrugated tube on impact resistance are investigated. The results indicate that optimal protection is achieved when the metamaterial’s unit cell wall thickness and angle are 0.6 mm and 21.250°, respectively. Results The overall structural response under nuclear blast loading demonstrates that, compared to the conventional bulkhead, the sandwich bulkhead with the quasi-static transformation-effect metamaterial reduces the maximum impact displacement by 58.53% and the maximum impact stress by 14.25%, while also exhibiting lower weight and spatial occupancy than the conventional bulkhead. Conclusions Metamaterials with the quasi-static transformation effect during impact show broad application prospects in the blast and impact-resistant design of ship and offshore engineering structures.